Myrbetriq (mirabegron) is a proprietary medication recommended for treating overactive bladder in adults and specific pediatric cases. It is formulated as an extended-release drug, and like other medications, it may elicit side effects, such as headaches.
Categorized under the drug class of beta-3 adrenergic agonists, Myrbetriq does not have a generic alternative.
The oral formulations of Myrbetriq include an extended-release tablet and extended-release granules, which, when mixed with water, create a liquid suspension. The extended-release nature of these forms ensures a gradual release of the medication into the body over an extended period.
More common side effects of Myrbetriq
Myrbetriq has the potential to induce various side effects, with some being more prevalent than others. These effects are often temporary, lasting from a few days to several weeks. If any side effects persist beyond this timeframe, cause significant discomfort, or become severe, it is crucial to consult with your healthcare provider or pharmacist.
Highlighted below are some of the frequently observed side effects reported by individuals participating in clinical trials with Myrbetriq:
- Constipation
- Headache
- Nasopharyngitis (inflammation of the nasal passages and throat)
- Urinary Tract Infection (UTI)
Note: The term "Urinary Tract Infection (UTI)" is specified separately to emphasize its inclusion among the common side effects.
Mild side effects of Myrbetriq
Myrbetriq use may lead to mild side effects, and the following list provides examples, although it is not exhaustive. For a more comprehensive understanding, you are encouraged to consult Myrbetriq's prescribing information.
Reported mild side effects associated with Myrbetriq comprise:
- Diarrhea
- Dizziness
- Dry mouth
- Fast heart rate
- Nausea
- Constipation
- Headache
- Nasopharyngitis (swelling of the nasal passages and throat)
- Urinary tract infection (UTI)*
- Mild allergic reaction*
These effects are typically of a temporary nature, lasting from a few days to several weeks. However, should these side effects persist beyond this duration, cause significant inconvenience, or become severe, it is advisable to seek guidance from your healthcare provider or pharmacist.
Note: The mention of "Urinary Tract Infection (UTI)" and "Mild Allergic Reaction" is highlighted separately for emphasis on their inclusion among the mild side effects.
Pros and Cons of myrbetriq
Pros of Myrbetriq
- Effectiveness in Treating Overactive Bladder
- Extended-Release Formulation
- Approved for Neurogenic Detrusor Overactivity (NDO) in Children
- Reduced Risk of Dry Mouth
Cons of Myrbetriq
- Potential Side Effects
- Drug Interactions
- Not Suitable for Everyone
Differences Between myrbetriq and carvedilol
Myrbetriq
Primarily indicated for the treatment of overactive bladder (OAB) symptoms, including urgency, frequency, and urinary incontinence.
Carvedilol
Used to manage conditions like hypertension (high blood pressure) and heart failure.
Alternative to myrbetriq
Antimuscarinic Medications
- Oxybutynin (Ditropan, Oxytrol): Blocks the action of acetylcholine, a neurotransmitter involved in bladder muscle contractions.
- Tolterodine (Detrol, Detrol LA): Also an antimuscarinic agent, it helps relax the bladder muscle.
Serious side effects of Myrbetriq
Myrbetriq has the potential to induce serious side effects, and the provided list may not encompass all potential severe reactions. It is advisable to consult Myrbetriq's prescribing information for a comprehensive understanding.
Should you experience serious side effects while using Myrbetriq, promptly contact your healthcare provider. In situations where the side effects appear life-threatening or if you believe you are facing a medical emergency, call 911 or your local emergency number without delay.
Reported serious side effects include:
- Angioedema*
- High blood pressure*
- Urinary retention*
- Severe allergic reaction†
Note: The terms "Angioedema," "High blood pressure," and "Urinary retention" are highlighted separately to underscore their inclusion among the serious side effects.
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Side effects in children
Myrbetriq has received approval for the treatment of neurogenic detrusor overactivity (NDO) in specific children aged 3 years and older.* NDO represents a subtype of overactive bladder (OAB), and the side effects observed in children were comparable to those seen in adults.
During clinical trials involving children taking Myrbetriq, the following side effects were reported:
- Constipation
- Headache
- Nasopharyngitis (swelling of the nasal passages and throat)
- Urinary tract infection (UTI)†
It is noteworthy that UTIs were more prevalent in children compared to adults.
In some instances, high blood pressure was noted among children in clinical trials.† The incidence of blood pressure increases was more significant in children aged 7 years and younger, with no reports in children aged 13 years and older.
If you have inquiries regarding Myrbetriq's side effects in children, it is advisable to consult with your child's doctor. They will provide guidance on whether the medication is suitable for your child.
Note: The age-specific details provided pertain to the approved age range for Myrbetriq use in treating neurogenic detrusor overactivity in children.
Please be aware that this information is based on clinical trial data, and any concerns or questions about the medication's effects on children should be discussed with a healthcare professional.
Precautions for Myrbetriq
Before taking Myrbetriq, it is crucial to discuss your health history with your doctor, as certain medical conditions or factors may impact the suitability of this medication for you. These considerations involve drug-condition or drug-factor interactions, including:
Allergic Reaction
If you've previously experienced an allergic reaction to Myrbetriq or any of its components, your doctor is likely to avoid prescribing it. You should inquire about alternative medications that may be more suitable for you.
Antimuscarinic Drugs
Concurrent use of Myrbetriq with antimuscarinic drugs, such as solifenacin (Vesicare), heightens the risk of urinary retention. If you are taking an antimuscarinic drug, inform your doctor before starting Myrbetriq to assess potential interactions.
Bladder Outlet Obstruction (BOO)
Although individuals with bladder outlet obstruction did not demonstrate an increased risk of urinary retention in clinical trials, caution is exercised when prescribing Myrbetriq to such individuals. If you have BOO, inform your doctor, who will provide guidance on whether Myrbetriq is suitable for you.
High Blood Pressure
Myrbetriq can elevate blood pressure. If you have poorly managed high blood pressure, your doctor may not recommend the drug. Inform your doctor of your high blood pressure status before starting Myrbetriq, and they may suggest more frequent blood pressure monitoring and offer advice on management.
Liver or Kidney Problems
Individuals with severe liver or kidney disease may experience Myrbetriq buildup, increasing the risk of side effects. In such cases, your doctor may explore alternative treatments or adjust the dosage. Inform your doctor of any liver or kidney problems before starting Myrbetriq.
Alcohol with Myrbetriq
There is no known interaction between alcohol and Myrbetriq. However, alcohol may exacerbate certain side effects of Myrbetriq, such as dizziness and headache. If you consume alcohol while taking Myrbetriq, discuss this with your doctor to determine a safe amount, if any, and to address potential worsening of side effects.
Pregnancy and Breastfeeding
The safety of taking Myrbetriq during pregnancy or breastfeeding is uncertain. Inform your doctor if you are pregnant or plan to become pregnant while on Myrbetriq, or if you intend to breastfeed. Together with your doctor, you can assess the risks and benefits to determine the appropriateness of Myrbetriq or explore alternative treatments.
Conclusion
Before embarking on Myrbetriq treatment, it is imperative to engage in open and thorough discussions with your healthcare provider regarding your health history. Myrbetriq may not be the ideal option if you have specific medical conditions or factors that could influence your well-being.
The considerations encompass potential interactions with allergic reactions, antimuscarinic drugs, bladder outlet obstruction, high blood pressure, and liver or kidney problems. Additionally, the impact of alcohol consumption and the uncertainties surrounding Myrbetriq use during pregnancy and breastfeeding should be addressed with your doctor.
By fostering transparent communication with your healthcare provider, you can collaboratively determine the most suitable course of action. Whether exploring alternative medications, adjusting dosages, or considering lifestyle factors, your doctor is equipped to guide you towards the most effective and safe treatment plan for your unique health needs. Remember, individualized discussions and informed decisions are key to ensuring your well-being while navigating the complexities of medical treatment.
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The content is intended to augment, not replace, information provided by your clinician. It is not intended nor implied to be a substitute for professional medical advice. Reading this information does not create or replace a doctor-patient relationship or consultation. If required, please contact your doctor or other health care provider to assist you to interpret any of this information, or in applying the information to your individual needs.