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Homepage | Health

Persistent Genital Arousal Disorder (PGAD): Causes, and Treatments

Isreal Olabanji DST, RNIsreal Olabanji DST, RNUpdated:March 8, 2026
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Persistent Genital Arousal Disorder (PGAD),  also known as Restless Genital Syndrome (ReGS or RGS), results in a spontaneous and persistent genital arousal, with or without orgasm or genital engorgement, unrelated to any feelings of sexual desire.
Some physicians use the term Persistent Sexual Arousal Syndrome to refer to the condition in women; others consider the syndrome of priapism in men to be the same disorder. In addition to being very rare, the condition is also frequently unreported by sufferers who may consider it shameful or embarrassing.
Persistent Genital Arousal Disorder (PGAD): Causes, Symptoms and Treatments Recommendations
Physical arousal caused by this syndrome can be very intense and persist for extended periods, days or weeks at a time. Orgasm can sometimes provide temporary relief, but within hours the symptoms return. The symptoms can be debilitating, preventing concentration on mundane tasks. Some situations, such as riding in an automobile or train, vibrations from mobile phones, and even going to the toilet can aggravate the syndrome unbearably.

PGAD can lead to ongoing physical pain, stress, and psychological difficulties due to an inability to carry out everyday tasks. The condition can affect women of all ages.
There is not enough medical evidence on this incidence of PGAD, Experts have not clinically confirmed the incidence of PGAD, as many people with the condition feel too embarrassed or ashamed to seek medical help.
Table of Contents
  1.  Persistent Genital Arousal Disorder Symptoms (PGAD)
  2. Causes Persistent Genital Arousal Disorder (PGAD)
  3. Treatment of Persistent Genital Arousal Disorder (PGAD)
  4. Recommendations For People Having Persistent Genital Arousal Disorder (PGAD)
  • References
  •  Persistent Genital Arousal Disorder Symptoms (PGAD)

    The sufferer might have a throbbing or tingling feeling in her genitals, increased blood flow to the area, or vaginal contractions.  Some women with PGAD have spontaneous orgasms.  But none of these symptoms is triggered by a sexual situation.

    They  include:

    • clitoris,
    • labia,
    • vagina,
    • perineum,
    • and anus.
    The sensations experienced are known as dysesthesias.


    And it often leads to:

    • wetness
    • itching
    • pressure
    • burning
    • pounding
    • pins and needles
    These can lead the person with PGAD to feel consistent like they are about to experience orgasm, or they may experience waves of spontaneous orgasms.

    The condition can lead to psychological symptoms due to the persistent discomfort and impact on day-to-day living.

    These may include:

    • Stress and anxiety can also cause or aggravate symptoms.
    • panic attacks
    • depression
    • distress
    • frustration
    • guilt
    • insomnia
    The use of SSRI antidepressants medication can lead the person with PGAD  to found herself suffering from restless leg syndrome and an overactive bladder. Both of these conditions are related to PGAD.


    People with chronic, or incurable, persistent genital arousal disorder believe there needs to be more research into PGAD. But what sufferers really want people to know is that it’s a pain disorder, rather than a sexual one.

    Causes Persistent Genital Arousal Disorder (PGAD)

    According to the people suffering from persistent genital arousal disorder, Sexual stimulation, masturbation, anxiety, and stress can trigger PGAD. In some women, stress causes the onset of the disorder. Once the stress is alleviated, they feel relief.

    However, this is not the case in every woman suffering from  PGAD. Research has implied a link between PGAD and the veins, hormones, nervous system, and chemical balance after using some types of medication.

    Also, there is a chance that cysts may also cause the condition. Tarlov cysts are sacs filled with spinal fluid that appear on the sacral nerve root. Sacral nerves at the bottom of the spine receive electrical signals from the brain, and they relay these instructions to the bladder, colon, and genitals.

    However, a standard medication for PGAD doesn’t exist. The condition is treated with everything from anti-neuralgic medicine usually prescribed for Parkinson’s disease, too, in some cases, Botox injections. The symptoms can be calmed, but not cured, and permanent frustration can have severe effects on mental health. This creates difficulty in diagnosing and treating the disorder.

    Treatment of Persistent Genital Arousal Disorder (PGAD)

    PGAD cure usually centers on managing symptoms, due to the often-unclear causes of the condition and varies from person to person.
    Gabapentin, a drug that eases nerve pain and was originally developed to treat epilepsy. The medication helps the person to cope with PGAD treatment, but it doesn’t relieve the symptoms entirely. “

    Now, the people suffering from persistent genital arousal disorder found a great deal of relief through the use of a transcutaneous electrical nerve stimulation (Tens) machine. This device, commonly used to treat back pain, sends small pulses of electricity into the base of the spinal column. Expert says the use of this device has made them practically PGAD-free.

    Women suffering from persistent genital arousal disorder can also undergo cognitive behavioral therapy , and most of them have finds out that activities such as mindfulness meditation and swimming help to keep them calm. But the underlying symptoms are unavoidable.
    Prescribed medication or changes in medication can help to manage the condition.

    In some cases, Changing current medications by removing drugs with herbal may be helpful. In nerve-related cases, such as a Tarlov cyst that I mentioned earlier on, the treating doctor may suggest surgery such as releasing the nerve from entrapment.

    PGAD is not yet curable. However, its symptoms can be managed on an ongoing basis to improve the quality of life of people with the condition and to reduce the psychological harm of PGAD.

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    Recommendations For People Having Persistent Genital Arousal Disorder (PGAD)

    Care of patients with PGAD begins by providing a safe and nonjudgmental atmosphere in which to facilitate an open and honest discussion. If PGAD is suspected, HCPs can consider referral to a sexual medicine provider or visit the International Society for the Study of Women’s Sexual Health (ISSWSH) website for more resources.
    RELATED READING
    • Anorexia Nervosa: Causes, Symptoms and Treatments
    • What are the different types of mood disorders?

    References

    • Persistent Genital Arousal Disorder (PGAD)
    • sexhealthmatters
    • MLA Felman, Adam. “What is persistent genital arousal disorder (PGAD)?.” Medical News Today. MediLexicon, Intl., 02 May. 2018. Web.
    • 02 May. 2018. medicalnewstoday
    • Eleanor Margolis. “Women with persistent genital arousal disorder: ‘People hear orgasm and they think it’s a good thing”. The Guardian,1 1 May. 2018. Web.
    • 02 May. 2018. theguardian

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    Isreal Olabanji DST, RN
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    Isreal Olabanji is a certified Dental Nurse in Nigeria with experience in oral health education, public health, dental instruments, and patient care. He writes evidence-based dental and oral health content for readers in Nigeria, the United States, and beyond, making expert oral care guidance accessible no matter where you're reading from. Follow me on Twitter, Facebook, Instagram, TikTok, Pinterest, or LinkedIn.

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