According to the American Cancer Society 1https://www.cancer.org/cancer/ovarian-cancer/about/key-statistics.html , ovarian cancer is the fifth highest cause of disease in women, accounting for more fatalities than any other cancer of the female reproductive system.
Ovarian cancer, which affects up to 250,000 women each year, is a quiet illness because most women do not notice symptoms until it is advanced. However, if detected early and before the cancer progresses, 90% of women can be healed. Advanced-stage ovarian cancer, in which the illness has gone beyond the ovaries, is more difficult to cure, and patient survival chances are lower.
While ovarian cancer is not as common as other types of cancer in women, a lack of early detection and prevention methods is a key cause of poor patient outcomes.
Knowing one's family history and obtaining genetic testing to find abnormalities in genes such as BRCA1 and BRCA2 are two ways for individuals to detect this cancer risk early. However, because most patients with ovarian cancer have no family history or inherited genetic risk, there is an urgent need to develop earlier detection technologies.
Why is early detection essential?
Early cancer detection often allows for more treatment options and gives patients the highest chance of a positive result.
New information about how BRCA1 and BRCA2 gene mutations contribute to ovarian cancer risk and response to therapy is helping women and their doctors make practical decisions about prevention and treatment.
All individuals with ovarian cancer or those with a family history of ovarian cancer should be offered genetic testing. However, it is estimated that 80% of ovarian cancer patients have never discussed genetic testing with their physicians.
With new treatments available, we must ensure cancer genetic testing is accessible.
Clinical trials have demonstrated that women with BRCA-related ovarian cancers benefit from including PARP inhibitors as part of their treatments. This has significantly changed how we approach genetic testing in relation to ovarian cancer.
With the emergence of targeted treatments like PARP inhibitors, which target cancers that rely on the PARP enzyme to repair damaged DNA, it becomes essential to determine a patient's BRCA status at the time of their diagnosis.
BRCA status helps determine which patients would benefit from PARP inhibitor treatment. These individualized treatments reinforce the importance of knowing the BRCA status of all women with ovarian cancer.
Detecting ovarian cancer early could have an enormous impact on the cure rate. Only about 20% of ovarian cancers are found at an early stage because symptoms often go undetected. When ovarian cancer is detected early, through measures like genetic screening, about 94% of patients live longer than five years after diagnosis. Early detection truly saves lives.
Before undergoing genetic testing for hereditary ovarian cancer, you should get genetic counseling to assess whether you and your family are likely to have a mutation that warrants testing.
Genetic testing at JScreen for hereditary ovarian cancer
Genetic testing for hereditary ovarian cancer checks for abnormalities in the BRCA1 and BRCA2 genes. Your doctor may recommend testing with a multigene panel, which screens for abnormalities in many genes at once, including BRCA1 and BRCA2.
If you have Ashkenazi Jewish or Eastern European heritage, your doctor may recommend testing for three BRCA1 and BRCA2 variants known as founder mutations. These are the most prevalent mutations in Ashkenazi Jews and others of Eastern European heritage.
While genetic testing has continued to improve the care and treatment of patients with ovarian cancer, it is also a vital tool for cancer prevention. “Making cancer genetic testing accessible is key,” said Jane Lowe Meisel, MD, Associate Professor of Hematology and Medical Oncology at Emory University School of Medicine and medical director for JScreen’s cancer program. "This testing is necessary because it alerts people to their risks before they get cancer.
For patients who are found to have mutations in the BRCA1 or BRCA2 gene, for example, they can consider prophylactic removal of the ovaries and fallopian tubes once they have completed childbearing, which reduces their risk of ovarian cancer significantly,” she adds.
How JScreen works
JScreen is a national non-profit public health initiative dedicated to preventing genetic diseases and cancer common in Jewish and other populations. Headquartered in Atlanta at Emory University School of Medicine, the JScreen initiative provides convenient at-home access to cutting-edge genetic testing technology, patient education, and counseling services. JScreen believes the combination of education, access to premier genetic screening technologies, and personalized, confidential support are the keys to preventing devastating diseases.
JScreen recently added CancerGEN to its testing portfolio, providing nationwide access to cancer genetic screening that is more affordable and accessible than ever.
With an understanding and awareness of their cancer risks and available options, people can work with their health-care providers on the next steps," said Karen Arnovitz Grinzaid, MS, CGC, Assistant Professor of Human Genetics at Emory University School of Medicine, and JScreen’s Executive Director. “With ovarian cancer, genetic testing can truly be a game-changer,” adds Grinzaid.
Getting tested through JScreen is easy. All you need to do to receive your simple at-home test kit is sign up online, provide a saliva sample and use pre-paid postage to mail it in.
JScreen’s tests use state-of-the-art genetic sequencing technology to ensure highly accurate results. Importantly, licensed genetic counselors provide consultations via phone or secure video conferencing to ensure that people understand their results.
Get affordable testing at Jscreen.
One of JScreen’s goals is to make testing affordable. JScreen’s CancerGEN test costs $199. The program also offers a separate test called ReproGEN for individuals or couples planning to have children - this test includes over 200 genetic diseases like Tay-Sachs, cystic fibrosis, and sickle cell disease that could impact a couple's future children. The ReproGEN test costs $149. JScreen also provides need-based financial assistance.
The proof of JScreen’s passion for saving lives is in the incredible stories, the people who can now take action to avoid a cancer diagnosis, and the healthy babies born. As the JScreen team likes to say – "we are a small team with a huge footprint."
Isreal olabanji a dental assistant and public health professionals and has years of experience in assisting the dentist with all sorts of dental issues.
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Additional resources and citations
- 1https://www.cancer.org/cancer/ovarian-cancer/about/key-statistics.html
The content is intended to augment, not replace, information provided by your clinician. It is not intended nor implied to be a substitute for professional medical advice. Reading this information does not create or replace a doctor-patient relationship or consultation. If required, please contact your doctor or other health care provider to assist you to interpret any of this information, or in applying the information to your individual needs.